support

Version 4.5.1 [11.10.2018]

1. (M/W) Resolved issue with Enzyme range selector in Mark Sites dialog

Version 4.5.0 [02.10.2018]

1. (M) Gatekeeper Path Randomization support
2. (M) Fixed License File copy bug on MacOS 10.13 (High Sierra)
3. (M) Fixed view drawing bug with Construct, Sequence and Illustration documents
4. (M) Added Toolbar icons as shortcuts for common menu actions
5. (M) Fixed an issue with Font Typeface discrepancies
6. (W) Updates for Windows 10 version 1709 (Fall Creators Update) compatibility
7. (W) Addressed problems with printing Constructs under certain conditions
8. (M/W) Fixed junction marker Copy/Paste issue
9. (M/W) Resolved issue with AutoFeature sequence matches at 3’ end of Construct
10. (M/W) Added extended support for Auto Annotation
11. (M/W) Updated drawing routines in Sequence and Construct windows

Version 4.0.3 [11.26.2013]

1. (M) Resolved Open Transport library issues with Mac OS X 10.9
2. (M) Added signed developer certificate to support Gatekeeper
3. (W) Addressed an issue printing arcs from Illustration
4. (M/W) Fixed an off by 1 error when marking a location at the origin
5. (M/W) Updated GenBank importer to support tab delimiters
6. (M/W) Fixed a problem with Gel lane order when multiple lanes are copied / pasted
7. (M/W) Restored run-off count to Gel lanes

Version 4.0.2 [03.10.2013]

1. (M) Resolved an issue under Mac 10.6 where sequence characters were missing from pasted PICT data
2. (M) Fixed a problem with Gel display in Illustration windows
3. (M) Fixed an issue with Sequence display in Illustration windows
4. (M/W) Updated GenBank export headers to adhere to changes in NCBI documentation
5. (M/W) Save last used settings from Find Sequence dialog to user preferences

Version 4.0.1 [11.27.2012]

1. (M/W) Added change case buttons to find sequence window
2. (M/W) Added arrow keys navigation support to find sequence window
3. (M) Added anti-alias drawing support for nucleotide characters in sequence view
4. (W) Fixed disabled radio buttons problem in find sequence window
5. (W) Fixed an issue with export DNA sequence as text

Version 4.0.0 [10.10.2012]

1. (M/W) Introduced new function to automatically find and format sequence features
2. (M/W) Implemented new feature to Copy / Paste construct styles
3. (M/W) Added Go to Position as navigation feature
4. (M/W) Implemented new Find Sequence search engine, supports search with mismatches in defined positions
5. (M/W) Added support to export GCK files in GenBank file format
6. (M/W) Added support for Undo / Redo for Make Region and Make Linear commands
7. (M/W) Added tooltips for help support text in Find Sequence and AutoFeature windows
8. (M/W) Updated Database Search routine to give all users free access
9. (M/W) Added ability to set arrow directionality in Region Info dialog
10. (M/W) Fixed a number of cosmetic issues with windows and dialogs
11. (M/W) Updated importer routine to handle Gene Inspector files
12. (M/W) Updated routines for handling copying protein sequences spanning introns
13. (M/W) Improved application stability with numerous bug fixes and code enhancements
14. (M) Improved export as JPEG to support JPEG 2000 standard
15. (M) Added anti-alias support for text in construct views
16. (W) Fixed an issue which could cause windows in the application to lose focus after opening multiple dialogs
17. (M/W) greatly enhanced speed of application

Version 3.5.3 [2.9.2012]

1. (M/W) Enhanced 'Find Sequence' routines to find degenerate nucleotide character in both target and source strings
2. (M/W) Resolved issue with 'List Sites' results window appearing blank when a large number of sites are displayed
3. (M) Resolved extension-type association problem opening files stored on Windows file servers using Services for Macintosh
4. (M/W) Fixed a cosmetic issue which displayed the search string as the reversed/inverse after performing a search
5. (M/W) Modified file read/write routines to speed up operation times by 20x
6. (M/W) Added transfer preferences option to enable better parsing of non-standard GenBank files
7. (W) Fixed rare occurrence of GCK preferences file becoming corrupted after updating Custom Colors
8. (M/W) Restored select enzymes by typing in the Mark Sites window

Version 3.5.2 [9.28.2011]

1. (W) Fixed an issue on Windows 32-bit systems that caused arcs to be missing when printed
2. (M/W) Resolved a conflict when the Recent Items menu contains files named with special / foreign characters or symbols
3. (W) Addressed a problem where Illustration images were not always displayed correctly
4. (W) Fixed an issue which sometimes caused GCK Gel and Illustration files to open as blank if the user double-clicked to launch
5. (M/W) Fixed an issue with the Legend in Gel files not correctly updating construct names that changed during a session
6. (W) Added support for recognizing older formatted GCK Gel Files
7. (W) Corrected the Export - Save As... menu to correctly display GCG File in the available options

Version 3.5.1 [7.13.2011]

1. (M) Fixed a problem copying and pasting sequence text with non-standard font sizes from external programs
2. (M/W) Fixed an issue with the General Info panel that sometimes caused selection / updating problems
3. (W) Addressed a problem where certain operations sent the active window to the background
4. (M/W) Updated GenBank Importer to utilize a generic conversion default if no user conversion defaults were present or defined
5. (M/W) Updated the Deluxe Importer parser to better handle non-standard GenBank files (i.e. older exports from Vector NTi with invalid file headers and spacing)
6. (M/W) Modified GCK to not clear the clipboard upon launch
7. (M) Fixed an issue in the Region Info panel, which caused text modifications to not update dynamically
8. (M/W) Fixed a problem with deselecting certain regions which sometimes caused a program crash
9. (M/W) Updated license manager for more consistent KeyServer compatibility (Network users only)

Version 3.5.0 [5.24.2011]

1. (M) Updated application bundle to Universal Binary for native Intel-based Macintosh computers
2. (M) Added support for Mac OS 10.7 (Lion)
3. (W) Addressed speed issues sometimes observed when working with files accessed across a network file server / USB drive
4. (M/W) Added edit menu options to right-click mouse button
5. (M/W) Updated font menu item to utilize standard operating system font panel
6. (M/W) Added keyboard shortcut (Command-T / CTRL-T) for accessing the Font palettes
7. (M/W) Added support for License Info panel to display license parameters
8. (M/W) Added support for exporting files in GCK 2.5 format
9. (M/W) GCK 3.5 now saves files in the earliest possible formats for backwards compatibility
10. (M/W) Addressed a selection problem in Illustration window that caused application to crash
11. (W) Fixed an intermittent problem where the active window would lose focus after performing multiple Deluxe Import or Mark Site operations
12. (M) Updated position indicator to update in real-time for nucleotide selections
13. (M/W) Fixed Deluxe Importer to save/restore text and popup selections
14. (W) Addressed problems copying and pasting DNA sequence text from PowerPoint
15. (M/W) Corrected a problem where AA’s displayed for a pasted protein sequence would not be shown in Illustration document
16. (M/W) Addressed instances where construct name would not appear centered
17. (M) Can now open construct files created on Windows with missing font names on the Mac
18. (W) Added alert for users trying to change the name of open file on Windows
19. (M/W) Fixed text selection problem with the General Info dialog
20. (M/W) Updated clipboard to appropriately deal with Copy / Paste from an external program into a 'sticky end' site
21. (W) Double-click on title bar to maximize file windows
22. (M/W) Updated construct to revert to default format for typed-in nucleotides
23. (M) Updated the construct window display to eliminate ghosting when dragging around construct title

Changes to Gene Construction Kit® 3.0

Version 3.0.4 [12.24.2009]

1. (M/W) Page setup parameters were not being saved
2. (M/W) Could not save files to SMB mounted volumes or to some USB thumb drives
3. (M/W) Fixed a problem that would not allow GCK to create new files under some circumstances when running shotgun cloning
4. (M) Fixed a problem that interfered with Deluxe Importing some GenBank files
5. (W) Fixed a problem with importing plain text DNA sequences
6. (M/W) Fixed a problem that would cause the program to quit when double-clicking a site marker in sequence view if the file had invalid data
7. (W) Fixed a problem that caused page breaks to be in the wrong place when printing a sequence view having Courier font in a size smaller than 18 pt
8. (M) Fixed a problem in the Recent Items menu so that if two items have the same name but in different directories their pathnames are shown
9. (M/W) Fixed a problem that would occur if the user tried to view a sequence window from a corrupted file

Version 3.0.3 [10.04.2009]

1. (W) Some functions send active window to the background
2. (M/W) page setup parameters are not being saved
3. (W) drag file to open doesn't work
4. (W) crash during export
5. (W) Windows Double-click to open files will not work if application already open
6. (M/W) Mark Sites doesn't remember previous settings
7. (M) Illustration - problems with enzyme cut site information display
8. (M/W) Three letter file extension displayed in construct title
9. (M/W) Deluxe Import - Pick a Width
10. (M/W) Deluxe Import - Size Arrowhead
11. (M/W) Conversion Defaults Panel - Deluxe Import; changed to allow very tall line widths and other features
12. (M/W) Search Files crashes application if 'Subdirectory' box is checked
13. (W) Get Info panel for enzyme sites shows wrong sequence
14. (M) Some GCK files cause app to crash under OS 10.5
15. (W) Conversion defaults panel font changes on Windows
16. (W) Incomplete error dialog text when creating introns over ORF start/stop
17. (M) Error code 30568, when trying to click in enzyme lists
18. (W) Fonts selector not correct in 'Default construct'

Version 3.0.2 [05.02.2009]

1. (M) fixed a problem that caused page setup parameters to not be saved
2. (M/W) increased allowable length of (enzyme) list names to 255 characters each
3. (M/W) increased allowable length of file names to system limit
4. (W) fixed a problem that did not allow user to drag file to application icon to open file
5. (W) fixed a problem that caused construct window to lose focus after DB search
6. (W) fixed installation problem that occurred on some systems
7. (W) corrected Gel Window export choices
8. (M/W) implemented multiple Undo and Redo options
9. (M/W) fixed problem when importing GCG files with comments containing '..'
10. (M/W) fixed problem that occurred some times when translating across an intron
11. (W) fixed problem that caused a crash when creating a new enzyme list file under some circumstances
12. (M) fixed a problem that caused a crash when exporting a formatted listing as text
13. (W) fixed cosmetic problems that occurred when maximizing a window
14. (W) fixed problem with importing GenBank (.gb) files created by some other programs
15. (W) fixed a problem when running both GI and GCK simultaneously
16. (M) fixed a problem when editing a feature name during deluxe importing
17. (M) fixed problem in pagination when printing long sequence files
18. (W) fixed selection problem after maximizing construct window

Version 3.0.1 [10.08.2008]

1. (M/W) fixed a problem in PCR annotation where under some circumstances, the right primer was not annotated correctly
2. (M/W) clarified output text in saved file generated from PCR results window

Version 2.0.6 [02.11.2018]

1. (M) Gatekeeper Path Randomization support
2. (M) Fixed License File copy bug on MacOS 10.13 (High Sierra)
3. (W) Updates for Windows 10 version 1709 (Fall Creators Update) compatibility

Version 2.0.5 [07.10.2014]

1. (M) Fixed an issue with exporting DNA / Protein sequence files under Mac OS X 10.9

Version 2.0.4 [05.12.2014]

1. (M) Resolved Open Transport library issues with Mac OS X 10.9

Version 2.0.3 [03.10.2013]

1. (M/W) Fixed problem with Text Box notebook extension not working
2. (M/W) Resolved issued causing Tables drawn in Notebook window to exhibit ghosting
3. (M/W) Updated button labels in the Table Spec creation window dialog
4. (M/W) Fixed an issue when Tables were created whose columns crossed the page boundaries, resulting in error code -9705

Version 2.0.2 [07.11.2012]

1. (M/W) Fixed an issue with character drawing when sequences are grouped
2. (M/W) Fixed problem with drawing extra "junk" characters at the end of a sequence line
3. (M) Updated drawing routines to better align sequence characters when using variable width fonts
4. (M) Added UTI types to identify GI files in File Open/Save dialogs
5. (M) Fixed problems with drawing underlined characters with variable width fonts

Version 2.0.1 [05.19.2012]

1. (M) Fixed a problem which caused shading to not update with font changes in aligned sequences
2. (M) Addressed a crash when importing nucleic acid and peptide sequence files
3. (M) Fixed an issue where analysis outputs were not drawn completely in notebooks
4. (W) Corrected problems importing multi-record GenBank sequence documents
5. (W) Updated support for font changes made through font panel selections

Version 2.0.0 [05.01.2012]

1. (M) Updated application bundle to Universal Binary for native Intel-based Macintosh computers
2. (M) Added support for Mac OS 10.7 (Lion)
3. (M) Added anti-alias support for fonts in notebook and sequence windows
4. (M) Reduced Analysis run-time by up to 90% with use of pre-emptive threads on Mac OS X
5. (M) Addressed a problem with file window boundary
6. (W) Updated font menu item to utilize standard operating system font panel
7. (W) Moved Gene Inspector data previously stored in the Programs folder into the users preference folder, to avoid use of VirtualStore folder
8. (W) Fixed an issue which could cause windows in the application to lose focus after performing an operation
9. (M/W) Improved application stability with numerous bug fixes and code enhancements
10. (M/W) Added Help menu options
11. (M/W) Added edit menu options to right-click mouse button
12. (M/W) Added support for License Info panel to display license parameters
13. (M/W) Updated the 'Custom Score Adornments' panel to match user selections
14. (M/W) Fixed a problem with copying and pasting notebook text into external applications

Version 1.6.9 [05.08.2009]

1. (M) analysis panel sometimes got visually corrupted when adding a sequence
2. (M/W) some old GCK files could not be imported properly
3. (M) Membrane Buried protein analysis sometimes quit unexpectedly when editing parameters
4. (M) Base Composition analysis sometimes quit unexpectedly when editing parameters

Version 1.6.8 [01.25.2008]

1. (M) corrected problem that sometimes prevented running applications in 10.5.1

Version 1.6.7 [10.05.2007]

1. (W) corrected wording in BLAST panel
2. (W) Help --> Product Updates menu option now links directly to update file
3. (W) fixed issue with loss of information from clipboard when GI notebook copy/paste with sub-selections of sequence
4. (W) updated BLAST searching to work with new protocols at NCBI
5. (M) fixed problem when opening a GI 1.5 notebook with internet analyses
6. (M) fixed problem where copying selected sequences sometimes copied all sequences
7. (M) fixed problem when adding sequence data to a consensus sequence
8. (M) fixed problem drawing some custom score adornments
9. (M) fixed problem when a notebook window picture crashes GI
10. (M) fixed highlighting problem when changing case of seq file
11. (M) fixed problem that did not allow protein dot matrix window size to be changed from 10
12. (M) fixed problem with restriction enzyme analysis

Version 1.6.6 (Mac Only) [06.28.2007]

1. Fixed background highlight problem when changing text to All Caps.
2. Changed sequence copy function to only copy selected and shown sequences to the clipboard.
3. Fixed problem which crashed GI when adding characters to the end of a sequence or pasting characters to the end of a sequence with consensus shading enabled.
4. Fixed problem which crashed GI when drawing boxes around consensus matches.

Version 1.6.5 [03.05.2007]

1. Updated file structures to be compatible with the newly released GI for Windows

Version 1.6.4 [03.25.2005]

1. Fixed a problem that sometimes lead to difficulties in opening older notebooks containing very large sequence analyses
2. Increased stability when working with large notebooks
3. Fixed a problem that did not allow window size to be changed in dot matrix analyses

Version 1.6.3 [01.22.2005]

1. Fixed a problem that sometimes lead to periodic crashes when command-dragging within the sequence editor to select multiple "columns" of sequence.
2. Tweaked a number of interface items to clarify user choices.
3. Fixed a number of sporadic cosmetic problems that arose when copying and pasting sequences between different sequence windows.
4. Changed some code to allow GI to handle very large (chromosome sized) sequences more reliably.
5. Changed GI preferences so that it can be launched from non-administrator accounts. Preferences are now stored individually for each user.
6. Starting with this version, all GI Data files are stored within the Application package itself. It is no longer necessary to maintain an external GI Data folder.
7. Fixed a cosmetic problem that sometimes cut off the right parts of dot matrix plots when a notebook was saved and then opened again.

Version 1.6.2 [08.14.2004]

1. Fixed a problem that did not allow copying from other applications into GI under a specific series of steps.
2. Fixed a problem that prevented dot matrix analysis from working under particular circumstances.
3. Enabled the copying of table results from the notebook to other applications.
4. Fixed a problem that did not allow dot size to be set in a dot matrix analysis.
5. Fixed a problem that did not allow the table column widths to be preserved in a saved notebook.

Version 1.6.1 [07.15.2004]

1. Fixed problem that produced inappropriate scrolling of a sequence window under some circumstances.