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Author Archives: Bob Gross, Ph.D., Textco BioSoftware
How living systems have helped in the evolution of computational problem solving
Today, we are being deluged with an enormous amount of biological data. Web sites abound that have genomes, gene expression data, transcription factor data, phylogenetic data, and the list goes on. The Genomes OnLine Database currently lists 6,423 genomes. They also list 249 metagenomes, which are “genomes” from whole microbial communities [1]. NCBI has a […]
Non-coding doesn’t ‘translate’ to non-functional when it comes to evolution
What is it that has allowed more “complex” species to evolve from simpler species? The popular notion that the addition of new protein coding genes is responsible for this increased complexity has been challenged over the last decade. It is becoming apparent that, although new proteins certainly are important, the amount of conserved sequence is […]
Evolution, Conservation, Change, Robustness, Complexity and Degeneracy
For species to be successful and adapt to an ever changing environment, they must strike a delicate balance between allowing for some DNA alterations, while at the same time preserving the key developmental processes encoded in their unique genomes. This poses a problem, as even small changes in any given gene might lead to deleterious […]
Gene Expression and Transcription Regulation
One of the main beliefs in biology today is that there is a relationship between genes that share common promoter motifs and their expression. It makes sense that if genes share common regulatory elements that they would be turned on and off under similar conditions – and thus would have similar microarray expression profiles. A […]
GenBank Converter 1.0 Released for Initial Beta Testing
GenBank Converter 1.0 Released for Initial Beta Testing Automated Converter Utility Offers New Flexibility West Lebanon, NH 1|12|2010 Today, Textco BioSoftware made the first beta release of the new GenBank Converter application (GBC) available for testing and feedback. The utility is designed to give users a convenient way to automatically convert GenBank formatted text files […]
How Genetic Algorithms Have Helped in Computational Problem Solving